Allergic reactions
Some people have hypersensitive immune systems that overreact to otherwise harmless things such as bee stings, foods, medications, and latex. Reactions range in severity: one person may break out in hives after eating shrimp; another may feel his or her throat closing up. In some cases, the person might pass out or have a heart attack. Without immediate medical treatment, allergic reactions can be fatal.
Causes
Allergic reactions involve proteins called antibodies that react to foreign substances called allergens—such as insect venom, a drug, or certain foods.
In sensitive individuals, being exposed to an allergen for the first time stimulates the body to produce antibodies to that allergen. These antibodies bind to special cells in the blood (basophils) and tissues (mast cells). When the individual is re-exposed to the allergen, those bound antibodies trigger the release of histamine and other chemicals that cause swelling and damage surrounding tissues.
Table 1. Medications and Other Substances Linked to Allergic Reactions
| Antibiotics |
| Cephalosporins |
| Ciprofloxacin |
| Nitrofurantoin |
| Penicillin and derivatives |
| Sulfonamides |
| Tetracycline |
| Vancomycin |
| Chemotherapy drugs |
| Asparaginase |
| Cyclosporine |
| 5-Fluorouracil |
| Methotrexate |
| Vincristine |
| Painkillers |
| Aspirin (Bayer) |
| Nonsteroidal anti-inflammatory drugs (NSAIDs) |
| Opiates |
| Other |
| Allergy extracts - such as those you might receive during immunotherapy (allergy shots) |
| Contrast dyes - used for diagnosing certain disorders |
| Dextran |
| Glucocorticoids |
| Heparin |
| Insulin |
| Human gamma globulin |
| Protamine |
| Vaccines |
| Latex - found in gloves and condoms |
Table 2. Foods Linked to Allergic Reactions
| Chocolate |
| Corn, cornmeal, or popcorn |
| Eggs |
| Fish |
| Fruits (apples, bananas, peaches, oranges, melons) |
| Legumes (beans, peanuts, peas, soybeans) |
| Milk products |
| Nuts (almonds, cashews, pecans, walnuts) |
| Potato |
| Seeds (cottonseed, poppy, sesame, sunflower) |
| Spices (cinnamon, nutmeg, mustard, sage) |
Symptoms
Allergic reactions produce an array of symptoms that can affect the skin, lungs and airways, and the heart and cirulatory system—usually within an hour of exposure. Table 03
Reactions range in severity. Typically, the faster symptoms come on the worse the reaction will be. Skin symptoms such as flushing and itchiness are typical. Red, raised swellings with a white center (hives) are another allergic skin reaction. Allergic reactions can cause swelling in the airways, making it hard to breathe. The person may feel the throat closing in or tightening in the chest. Sometimes blood pressure drops quickly and causes weakness and fainting, or the heart starts beating erratically. This places the person in a state of extreme distress. He or she may feel nauseous and vomit.
Table 3. Symptoms of Allergic Reactions
| Skin | flushing, redness, hives, itching |
| Eye and Nose | red, watery eyes; runny nose, congestion, sneezing |
| Respiratory | Throat swelling, chest tightness |
| Cardiovascular | Heartbeat abnormalities, severe drop in blood pressure, dizziness |
| Gastrointestinal | Abdominal pain, nausea and vomiting |
Risk Factors
People who have a history of allergies are the most likely to have an allergic reaction.
Allergic reactions from aspirin and latex occur more frequently in women, and those from insect stings occur more frequently in men. This seems to have more to do with exposure than gender. People who have heart disease or asthma tend to have more severe allergic reactions than others.
Diagnosis
Allergic reactions are serious and potentially life-threatening, and can cause injury to tissues throughout the body.
Some people have hypersensitive immune systems that overreact to otherwise harmless things such as bee stings, foods, medications, and latex. Reactions range in severity: one person may break out in hives after eating shrimp; another may feel his or her throat closing up. In some cases, the person might pass out or have a heart attack. Without immediate medical treatment, allergic reactions can be fatal.
Allergic reactions involve proteins called antibodies that react to foreign substances called allergens—such as insect venom, a drug, or certain foods.
In sensitive individuals, being exposed to an allergen for the first time stimulates the body to produce antibodies to that allergen. These antibodies bind to special cells in the blood (basophils) and tissues (mast cells). When the individual is re-exposed to the allergen, those bound antibodies trigger the release of histamine and other chemicals that cause swelling and damage surrounding tissues.
Table 1. Medications and Other Substances Linked to Allergic Reactions
| Antibiotics |
| Cephalosporins |
| Ciprofloxacin |
| Nitrofurantoin |
| Penicillin and derivatives |
| Sulfonamides |
| Tetracycline |
| Vancomycin |
| Chemotherapy drugs |
| Asparaginase |
| Cyclosporine |
| 5-Fluorouracil |
| Methotrexate |
| Vincristine |
| Painkillers |
| Aspirin (Bayer) |
| Nonsteroidal anti-inflammatory drugs (NSAIDs) |
| Opiates |
| Other |
| Allergy extracts - such as those you might receive during immunotherapy (allergy shots) |
| Contrast dyes - used for diagnosing certain disorders |
| Dextran |
| Glucocorticoids |
| Heparin |
| Insulin |
| Human gamma globulin |
| Protamine |
| Vaccines |
| Latex - found in gloves and condoms |
Table 2. Foods Linked to Allergic Reactions
| Chocolate |
| Corn, cornmeal, or popcorn |
| Eggs |
| Fish |
| Fruits (apples, bananas, peaches, oranges, melons) |
| Legumes (beans, peanuts, peas, soybeans) |
| Milk products |
| Nuts (almonds, cashews, pecans, walnuts) |
| Potato |
| Seeds (cottonseed, poppy, sesame, sunflower) |
| Spices (cinnamon, nutmeg, mustard, sage) |
Allergic reactions produce an array of symptoms that can affect the skin, lungs and airways, and the heart and cirulatory system—usually within an hour of exposure. Table 03
Reactions range in severity. Typically, the faster symptoms come on the worse the reaction will be. Skin symptoms such as flushing and itchiness are typical. Red, raised swellings with a white center (hives) are another allergic skin reaction. Allergic reactions can cause swelling in the airways, making it hard to breathe. The person may feel the throat closing in or tightening in the chest. Sometimes blood pressure drops quickly and causes weakness and fainting, or the heart starts beating erratically. This places the person in a state of extreme distress. He or she may feel nauseous and vomit.
Table 3. Symptoms of Allergic Reactions
| Skin | flushing, redness, hives, itching |
| Eye and Nose | red, watery eyes; runny nose, congestion, sneezing |
| Respiratory | Throat swelling, chest tightness |
| Cardiovascular | Heartbeat abnormalities, severe drop in blood pressure, dizziness |
| Gastrointestinal | Abdominal pain, nausea and vomiting |
People who have a history of allergies are the most likely to have an allergic reaction.
Allergic reactions from aspirin and latex occur more frequently in women, and those from insect stings occur more frequently in men. This seems to have more to do with exposure than gender. People who have heart disease or asthma tend to have more severe allergic reactions than others.
To determine what is causing your symptoms, the doctor will conduct a medical history and do a physical examination.
Allergic reactions are pretty obvious, as the symptoms usually come on shortly after exposure to the allergen. The physician treating you will check your blood pressure, pulse, and respiration, and ask you if you were exposed to any possible triggers (foods, medications, stings, etc.) prior to the reaction.
The doctor may refer you to an allergist for skin tests.
Skin tests involve injecting tiny amounts of various allergens (insect venoms, drugs, etc.) into your skin and waiting to see if a skin reaction occurs. If you are allergic to any of them, a hivelike swelling should form within 20 minutes.
After you have received the emergency medical treatment necessary—a combination that could include epinephrine (adrenaline), an antihistamine or corticosteroids, or heart drugs to stop an abnormal heart rhythm—and are stable, your doctor may run diagnostic tests to determine what caused the reaction.
The doctor may wish to check blood levels of antibodies to specific allergens with a test called the radioallergosorbent test (RAST). X-rays will be taken if you have breathing symptoms or chest pain.
If a food is the suspected culprit, you may be asked to take tests to isolate the specific cause.
Diagnosing food allergies sometimes requires detective work. After a positive skin test, your allergist may have you consume the suspected trigger food disguised in something (such as applesauce) and wait for a reaction. Your allergist may also wish to have you follow an elimination diet. For this test, you begin by cutting out all possible allergenic foods. Then, you start adding them back, one at a time, to see if a reaction occurs. As the name suggests, this diagnostic tool works by process of elimination.
Alert your doctor to any known drug allergies you have and read package inserts before taking any medication.
Steer clear of any drug to which you have a known allergy. In addition, stay away from drugs that are related to your known allergen, as related medications could cause a reaction as well. For example, if you are allergic to aspirin, do not take NSAIDs (ibuprofen, ketoprofen, naproxen, etc.); if you are allergic to penicillin, let your doctor know so he or she will not prescribe penicillin-related medications, such as amoxicillin. Always read package inserts for warnings just in case.
Read food labels and look for ingredients that could trigger an allergic reaction. Take precautionary measures when preparing food and dining out.
If you know you are allergic to shrimp, obviously you know to pass on the shrimp cocktail. However, be aware that shrimp may be hidden in salads, casseroles, and other dishes. Be sure to ask before you eat. Some people are so sensitive that the steam from shellfish being cooked can trigger a reaction. These people should avoid restaurants with open kitchens or hibachi-style cooking tables.
Peanut allergies can be very severe and can occur at the slightest exposure. There have been reports of allergic reactions occurring in children who ate sandwiches that were cut with the same knife used to make peanut butter and jelly sandwiches for other kids. Be sure the cafeteria workers at your child’s school know of any allergies your child may have. Be sure to inform the parents of your child’s friends as well, to cut the risk that harmful food is served to your child unknowingly. When grocery shopping, read food labels carefully, checking for ingredients that may trigger reactions. Eggs may show up in ingredient lists as albumin, binders, or emulsifiers. The ingredients casein, lactose, and whey are derived from milk. When dining out, let the waiter or waitress know you have a food allergy and ask about the ingredients in the dish you are considering.
If you are highly allergic to stings, you may want to consider a treatment known as allergen immunotherapy to desensitize yourself to the allergen. Latex desensitization is not available in the U.S. Food immunotherapy is not effective, and may be dangerous.
For this therapy, a small amount of allergen is injected under the skin. The amount is too small to cause a reaction, but large enough to block or damp down any reaction that might occur with subsequent exposure to the allergen.
Prevention and Screening
Alert your doctor to any known drug allergies you have and read package inserts before taking any medication.
Steer clear of any drug to which you have a known allergy. In addition, stay away from drugs that are related to your known allergen, as related medications could cause a reaction as well. For example, if you are allergic to aspirin, do not take NSAIDs (ibuprofen, ketoprofen, naproxen, etc.); if you are allergic to penicillin, let your doctor know so he or she will not prescribe penicillin-related medications, such as amoxicillin. Always read package inserts for warnings just in case.
Read food labels and look for ingredients that could trigger an allergic reaction. Take precautionary measures when preparing food and dining out.
If you know you are allergic to shrimp, obviously you know to pass on the shrimp cocktail. However, be aware that shrimp may be hidden in salads, casseroles, and other dishes. Be sure to ask before you eat. Some people are so sensitive that the steam from shellfish being cooked can trigger a reaction. These people should avoid restaurants with open kitchens or hibachi-style cooking tables.
Peanut allergies can be very severe and can occur at the slightest exposure. There have been reports of allergic reactions occurring in children who ate sandwiches that were cut with the same knife used to make peanut butter and jelly sandwiches for other kids. Be sure the cafeteria workers at your child’s school know of any allergies your child may have. Be sure to inform the parents of your child’s friends as well, to cut the risk that harmful food is served to your child unknowingly. When grocery shopping, read food labels carefully, checking for ingredients that may trigger reactions. Eggs may show up in ingredient lists as albumin, binders, or emulsifiers. The ingredients casein, lactose, and whey are derived from milk. When dining out, let the waiter or waitress know you have a food allergy and ask about the ingredients in the dish you are considering.
If you are highly allergic to stings, you may want to consider a treatment known as allergen immunotherapy to desensitize yourself to the allergen. Latex desensitization is not available in the U.S. Food immunotherapy is not effective, and may be dangerous.
For this therapy, a small amount of allergen is injected under the skin. The amount is too small to cause a reaction, but large enough to block or damp down any reaction that might occur with subsequent exposure to the allergen.
Treatment
Seek medical attention right away if you have an allergic reaction—especially if you have trouble breathing or swallowing.
Allergic reactions can be life-threatening. Even if you have stabilized yourself with medications, you should still see a doctor who can monitor your cardiovascular and respiratory symptoms. Some people with severe allergies may even carry around their own dose of epinephrine (Epi-pen) that can be injected into the thigh in emergency situations—for example, a child allergic to bees may carry epinephrine if he or she goes away to camp or spends time outdoors.
If you have ever had an allergic reaction, carry a kit containing epinephrine (adrenaline) with you for emergencies. Epinephrine injections are needed to stop an attack of anaphylaxis, the most severe form of allergic reaction. Wear an ID bracelet or necklace stating information about any allergies you may have.
In the event of an allergic reaction, you will need to inject yourself with epinephrine to halt the reaction. The Epi-pen is a convenient spring-loaded gadget that automatically delivers a dose of epinephrine when pressed against the leg or another area. Even if you have had a dose of epinephrine, you still need medical help. Injecting yourself with epinephrine will ease your symptoms and enable you to seek further medical care.
Your doctor is the best source of information on the drug treatment choices available to you.
If you have severe allergies and cannot avoid triggers, you may want to consider allergen immunotherapy to desensitize yourself.
Your allergist will inject you (once a week at first; then once every four to six weeks) with minuscule amounts of the allergen, gradually increasing the dose until a maintenance level is found. This signals your body to produce substances that block allergic reactions. Allergen immunotherapy must be done carefully because too high a dose could prompt a reaction. Allergen immunotherapy is most effective when maintenance injections are given for a year. Because an injection might trigger an allergic reaction, you will have to stay in the doctor’s office for 20 minutes afterwards.
If you take beta-blockers and have a severe allergic reaction, epinephrine might not reverse it.
In this case, you will need to be given glucagon intravenously to bring your blood pressure back up.
With proper treatment, prognosis is excellent.
If you get help on time, anaphylaxis can usually be stopped with relative ease. Preventing another event is the next major concern. Avoiding allergens and, in some cases, undergoing allergen immunotherapy, can prevent recurrence. If you have life-threatening anaphylaxis without knowing what causes it, you will need to take preventative medications (antihistamines, oral albuterol, and corticosteroids).
If you have suffered a serious allergic reaction, you should be evaluated by an allergist.
